Custom mRNA-LNP 서비스
- 풀 QC 패널을 갖춘 고품질 mRNA
- 생산 규모, 안정성, 화학적 변형까지 맞춤 설계 가능
- 설계부터 제조까지 원스톱 전 과정 지원
장점
-
향상된 안정성
LNPs는 mRNA의 분해를 방지하여 완전성을 유지하고 효과적인 전달을 보장합니다. -
향상된 전달
최적화된 LNPs는 세포 흡수와 표적 전달을 향상시킵니다. -
면역원성 감소
면역원성 감소는 원치 않는 면역 반응을 최소화합니다.
상세내용
| Catalog | Capping and modification | Gene | Quantity | Timeline(Business days) |
|---|---|---|---|---|
| mRNA-LNP | Custom mRNA Cap1 in LNP | Custom gene or off-the-shelf | 100μg-20mg | 10-25 |
*Additional time (~2-3 weeks ) for custom gene synthesis
mRNA grade and QC standard
| QC category | QC item | Method | Specification | Research Grade |
|---|---|---|---|---|
| mRNA-LNP (On-shelf and Custom) |
RNA Integrity/size | Capillary Electrophoresis | >80% | √ |
| Encapsulate Efficiency | Elisa Analyzer | Report | √ | |
| Particle size | Dynamic Light Scattering | <120nm | √ | |
| Particle Uniformity | Dynamic Light Scattering | <0.2 | √ | |
| Concentration | Capillary Electrophoresis | Encapsulated mRNA >0.2mg/mL | √ |
PackGene’s quality control (QC) testing of mRNA lipid nanoparticles (LNPs) includes measurement of various parameters to ensure their quality, safety, and efficacy. Some of the essential QC tests for mRNA LNP are encapsulation efficiency, particle size, and uniformity.
품질
-
mRNA-LNP performance
EGFP mRNA (Cap1) -LNP
Z Ave. Dia (nm) 76.8 PDI PDI Encapsulation Efficiency 93.91% -
mRNA-LNP Gene Delivery in Animal
